Dimethyl Sulfoxide
Apexbio Technology LLC Fluoxetine HCl(Synonyms: Prozac, Sarafem, Fluoxetine Hydrochloride, Lilly 110140, Fluoxeren, Fluctin), 10mM (in 1mL DMSO), CAS: 56296-78-7.
Fluoxetine HCl (CAS 56296-78-7) is a selective serotonin reuptake inhibitor (SSRI) that specifically blocks presynaptic serotonin (5-HT) transporters resulting in elevated extracellular serotonin levels It modulates serotonergic signaling through inhibition of serotonin-induced membrane currents in cloned 5HT2C receptors exhibiting an IC50 around 20 M and binds 5HT2C receptors expressed in HeLa cells (Ki approximately 65-97 nM) Fluoxetine treatment has been shown in vivo to stimulate neurogenesis and enhance neuronal maturation and synaptic plasticity within rat hippocampus and prefrontal cortex Widely employed in neuroscience research fluoxetine aids in studies of depression stress resilience and neuro-regulatory mechanisms involving serotonergic signaling
Apexbio Technology LLC Cobimetinib 934660-93-2 10mM (in 1mL DMSO)
Cobimetinib (CAS 934660-93-2) is a selective small molecule inhibitor targeting mitogen-activated protein kinase kinase (MEK) MEK functions as a kinase that specifically phosphorylates serine/threonine and tyrosine residues playing a critical role in the MAPK signaling cascade and modulating cell proliferation survival migration differentiation and angiogenesis Cobimetinib effectively inhibits MEK with an IC50 value of 0 9 nM demonstrating potent activity in various experimental cancer models including breast cancer cells harboring KRAS and B-RAF mutations In xenograft mouse models it exhibits dose-dependent tumor growth suppression and sustained inhibition of ERK phosphorylation Cobimetinib is currently evaluated in phase I clinical trials as an anticancer therapeutic candidate
![Apexbio Technology LLC Scriptaid(Synonyms: Scriptaid, HDAC inhibitor Scriptaid, 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide), 10mM (in 1mL DMSO), CAS: 287383-59-9.](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000060690.PNG-250.jpg)
Apexbio Technology LLC Scriptaid(Synonyms: Scriptaid, HDAC inhibitor Scriptaid, 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide), 10mM (in 1mL DMSO), CAS: 287383-59-9.
Scriptaid (CAS 287383-59-9) is a small-molecule histone deacetylase (HDAC) inhibitor originally identified through high-throughput transcriptional screening It specifically targets class I HDAC isoforms inhibiting HDAC1/HDAC3 and HDAC8 with IC50 values of approximately 0 6 M and 1 M respectively Structurally related to other hydroxamic acid-containing HDAC inhibitors such as TSA Scriptaid consists of a hydroxamic acid moiety a connecting linker and an aromatic cap group In glioblastoma (GBM) research Scriptaid shows promise by inducing apoptosis in glioma cells highlighting its potential utility for oncology-focused investigations
Apexbio Technology LLC Flumethasone 2135-17-3 10mM (in 1mL DMSO)
Flumethasone is a glucocorticoid receptor agonist functioning by binding to intracellular glucocorticoid receptors (GR) and forming a receptor-ligand complex Upon formation this complex translocates into the nucleus modulating transcriptional activity through interactions with glucocorticoid response elements (GREs) subsequently altering gene expression patterns that regulate inflammation immune responses and cellular metabolism Flumethasone is commonly used in biomedical research involving inflammatory and autoimmune disease models to investigate glucocorticoid-mediated regulatory mechanisms receptor signaling pathways and gene expression modulation Reported GR-binding assays indicate Flumethasone exhibits an IC50 value in the low nanomolar range reflecting its potent receptor affinity allowing quantitative analyses and mechanistic studies on glucocorticoid-mediated biological effects
Apexbio Technology LLC LY2886721 1262036-50-9 10mM (in 1mL DMSO)
LY2886721 (CAS 1262036-50-9) is an orally bioavailable inhibitor of -site amyloid precursor protein cleaving enzyme 1 (BACE1) an aspartyl protease integral to amyloid precursor protein (APP) cleavage and amyloid- (A ) generation LY2886721 inhibits BACE1 activity with an IC50 of approximately 20 3 nM effectively reducing soluble APP and elevating soluble APP in human cell models (HEK293Swe) and neuronal cultures (PDAPP) at IC50 values of 18 7 nM and 10 7 nM respectively In animal models such as PDAPP mice oral LY2886721 administration dose-dependently reduces cerebral A C99 and sAPP levels Due to its BACE1 inhibitory action LY2886721 serves as a valuable tool in Alzheimer s disease research and therapeutic development
Apexbio Technology LLC JSH-23 749886-87-1 10mM (in 1mL DMSO)
JSH-23 (CAS 749886-87-1) is a small-molecule inhibitor of NF- B transcriptional activity exhibiting an IC50 of approximately 7 1 M Mechanistically JSH-23 prevents NF- B-mediated gene transcription by reducing nuclear localization and DNA binding activity of the NF- B p65 subunit without interfering with I B degradation In LPS-stimulated RAW 264 7 macrophages JSH-23 decreases expression of pro-inflammatory mediators including IL-6 IL-1 COX-2 and TNF- and inhibits apoptotic chromatin condensation This compound serves as a research tool for studying NF- B signaling and related inflammatory processes
Apexbio Technology LLC Vinorelbine 71486-22-1 10mM (in 1mL DMSO)
Vinorelbine is a semisynthetic vinca alkaloid derived from the plant Catharanthus roseus (L ) G Don Structurally characterized by its ability to bind selectively to tubulin this compound inhibits microtubule polymerization and disrupts mitotic spindle function leading to cell cycle arrest in metaphase and subsequent apoptosis Due to these antimitotic properties vinorelbine is extensively employed in biomedical research focused on investigating cell proliferation mechanisms understanding tumor biology and evaluating cytotoxicity profiles in vitro and in vivo Commonly utilized as a chemotherapy agent it serves as a research tool in studies of cancer pharmacology and drug resistance modeling Vinorelbine must be stored in a properly sealed container under cool dry conditions to maintain its chemical stability and biological activity for experimental use
Apexbio Technology LLC Epirubicin HCl 56390-09-1 10mM (in 1mL DMSO)
Epirubicin HCl is an anthracycline antibiotic with antitumor activity targeting DNA topoisomerase II (TOPII) It functions by stabilizing TOPII-DNA cleavable complexes resulting in increased DNA double-strand breaks subsequent activation of DNA damage responses and initiation of apoptosis pathways Consequently epirubicin is frequently utilized in anticancer research particularly against osteosarcoma cells Studies demonstrate epirubicin induces apoptosis in osteosarcoma models yet it can also activate resistance pathways such as NF- B affecting therapeutic efficacy The reported IC50 values of epirubicin in osteosarcoma cell lines typically range between approximately 0 1 to 2 M based on experimental conditions This compound is thus actively employed in oncology research exploring DNA-damaging agents or combination therapy strategies in cell-based assays and animal models
Apexbio Technology LLC Elvitegravir (GS-9137) 697761-98-1 10mM (in 1mL DMSO)
Elvitegravir (GS-9137) is an integrase inhibitor targeting HIV-1 which impedes viral DNA integration during the replication cycle of human immunodeficiency virus type 1 (HIV-1) Its mechanism involves inhibition of the integrase enzyme-mediated DNA strand transfer reaction thereby preventing the insertion of viral genetic material into host genomic DNA and subsequently decreasing viral replication Reported inhibitory concentrations (IC50) against HIV-1 integrase range approximately from 7 to 8 nM Besides its application in HIV-1 research Elvitegravir demonstrates inhibitory effects against other retroviral integrases such as murine leukemia virus (MLV) and simian immunodeficiency virus (SIV) making it suitable for broader antiviral research use
Apexbio Technology LLC ABT-737 852808-04-9 10mM (in 1mL DMSO)
ABT-737 (CAS 852808-04-9) is a small molecule inhibitor targeting the BCL-2 protein family exhibiting high binding affinity toward the anti-apoptotic proteins BCL-2 BCL-X L and BCL-w ABT-737 disrupts BCL-2/BAX protein interactions leading to apoptosis primarily via the BAK-mediated intrinsic pathway independent of BIM In preclinical studies ABT-737 demonstrated single-agent antitumor activity in lymphoma multiple myeloma and small-cell lung cancer models Additionally research indicates activity against acute myeloid leukemia (AML) cells progenitor cells and leukemia stem cells while sparing normal hematopoietic populations highlighting its potential for therapeutic research in hematologic malignancies
Apexbio Technology LLC PD 151746 179461-52-0 10mM (in 1mL DMSO)
PD 151746 is a cell-permeable inhibitor that selectively targets calpain a calcium-dependent cysteine protease involved in various cellular processes With a Ki value of 0 26 M against -calpain it prevents the proteolytic cleavage of substrates like neuronal nitric oxide synthase (nNOS) and calmodulin-dependent protein kinase II-alpha (CaMPK-II) particularly under stress In neuronal models PD 151746 inhibits apoptosis induced by serum/potassium withdrawal reduces MEF2 phosphorylation suppresses cdk5/p25 complex formation and decreases caspase-3 activation In HepG2 hepatoma cells it disrupts insulin-stimulated glycogen synthesis and affects protein tyrosine phosphatase-2 (PTP2) expression PD 151746 is used in research to study calpain-related signaling pathways apoptosis cell motility and metabolism
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 50mL
Dimethyl sulfoxide (DMSO) (GMP Like) is the GMP Like class Dimethyl sulfoxide (HY-Y0320C) Dimethyl sulfoxide is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1]
Apexbio Technology LLC BI 2536(Synonyms: BI-2536, BI2536, Plk1 inhibitor BI 2536), 10mM (in 1mL DMSO), CAS: 755038-02-9.
BI 2536 (CAS number 755038-02-9) is an ATP-competitive inhibitor selectively targeting human polo-like kinase 1 (PLK1) exhibiting an IC50 value of approximately 0 83 nM Comparatively BI 2536 shows substantially less affinity towards other kinases In vitro studies demonstrate that BI 2536 inhibits proliferation of various human tumor cell lines (EC50 values ranging from 2 to 25 nM) and induces G2/M cell cycle arrest accompanied by apoptosis as evidenced in HeLa cervical cancer cells In vivo data from xenograft tumor models indicate that BI 2536 administered intravenously on a weekly or biweekly schedule possesses antitumor efficacy
Apexbio Technology LLC PCI-32765 (Ibrutinib) 936563-96-1 10mM (in 1mL DMSO)
PCI-32765 (Ibrutinib) is a small-molecule inhibitor targeting Bruton s tyrosine kinase (BTK) a cytoplasmic kinase integral to B-cell receptor (BCR) signaling By covalently binding to BTK active sites PCI-32765 disrupts downstream signaling cascades essential for B-cell maturation and activation Dysfunction or inhibition of BTK correlates with impaired B-cell development and reduction in autoantibody production PCI-32765 is commonly utilized in biomedical research to explore BTK-dependent signaling pathways elucidate molecular mechanisms underlying B-cell mediated disorders and examine therapeutic potential in B-cell malignancies and autoimmune models
Apexbio Technology LLC Nexturastat A 1403783-31-2 10mM (in 1mL DMSO)
Nexturastat A (CAS 1403783-31-2) is a selective small-molecule inhibitor of histone deacetylase 6 (HDAC6) It displays potent inhibitory activity against HDAC6 with an IC50 of 5 2 nM While predominantly targeting HDAC6 Nexturastat A also exhibits moderate inhibitory effects on other HDAC isoforms (HDAC1-5 and 7-11) at low micromolar concentrations In cell-based studies including mouse B16 melanoma cell lines Nexturastat A has shown antiproliferative properties and induction of apoptosis Due to its selective HDAC6 inhibition Nexturastat A is utilized in cancer research focusing on epigenetic regulation and therapeutic development